Brain and Biomarker Laboratory

The Brain and Biomarker Laboratory (BABL), under the direction of Dr. Lauren Ethridge, is a multidisciplinary, translational neuroscience laboratory focusing on applications of basic science to clinical outcomes, particularly in neurodevelopmental disorders.

The BABL group centers on the use of dense-array EEG as a translational tool for learning more about brain function in neurodevelopmental disorders. The ultimate goal of our research is to establish non-invasive biological markers for changes in brain function that not only elucidate neural and molecular pathways affected by disorders such as Autism Spectrum Disorder (ASD) and but also serve as aids for early identification, early predictors for response to individualized treatment protocols, and reliable indicators of treatment effects.

Research in the lab is highly collaborative, with a large network of investigators across the country. Current research includes:

  1. EEG as a translational, treatment sensitive, biomarker in rare genetic disorders associated with autism, including Fragile X Syndrome and Phelan-McDermid Syndrome
  2. Neural correlates of face processing in toddlers at risk for autism
  3. Characteristics of EEG activity related to variation in ASD symptoms across the full spectrum

Latest News





BABL Lab Team

Lauren Ethridge

Lauren Ethridge, Ph.D.
Principal Investigator

Lisa DeStefano

Lisa DeStefano, M.S.
Graduate Student

Nick Woodruff

Nick Woodruff
Graduate Student

Lindsey Tate

Lindsey Tate, M.S.
Graduate Student

Will Bauer

Will Bauer
Undergrad Student

Kara Brown

Kara Brown
Undergrad Student

Warren Chun

Warren Chun
Undergrad Student

Marie Fawadr

Marie Fawad
Undergrad Student

John Griffin

John Griffin
Undergrad Student

Karlie Hamman

Karlie Hamman
Undergrad Student

Rachel Jenks

Rachel Jenks
Undergrad Student

Joy Li

Joy Li
Undergrad Student

Jordan Norris

Jordan Norris
Undergrad Student

Scarlett Pollard

Scarlett Pollard
Undergrad Student

Neal Rangu

Neal Rangu
Undergrad Student

Angel Scribner

Angel Scribner
Undergrad Student

Cierra Stafford

Ciera Stafford
Undergrad Student

Farris Tedder

Farris Tedder
Undergrad Student

Morgan Tran

Morgan Tran
Undergrad Student

Madison Weaver

Madison Weaver
Undergrad Student

Emily Zhou

Emily Zhou
Undergrad Student



Former BABL Lab Members

  • Adam Wagner - now at OUHSC DO program
  • Eryn Jordan - now at OUHSC Master's of Occupational Therapy Program
  • Jeff Bogard - now at OUHSC MD program
  • Madeline Washburn
  • Madison Salem
  • Mackenzie Mills
  • Elijah Stafford
  • Sarah McKinzie
  • Emily Allen
  • Jessica McConahey

    BABL Collaborators

      OU/OUHSC

    • Dr. David Bard, Pediatrics
    • Dr. Ami Bax, Pediatrics
    • Dr. Barbara Carlson, Nursing
    • Dr. Lei Ding, Electrical and Computer Engineering
    • Dr. Andrew Fagg, Computer Science and Bioengineering
    • Dr. Bonnie McBride, Pediatrics
    • Dr. Michael Wenger, Psychology
    • Dr. Han Yuan, Biomedical Engineering

    External Collaborators

    • Dr. Jay Gibson, UT Southwestern Medical Center
    • Dr. Kim Huber, UT Southwestern Medical Center
    • Dr. Craig Powell, UT Southwestern Medical Center
    • Dr. John Sweeney, University of Cincinnati
    • Dr. Craig Erickson, Cincinnati Children’s Hospital
    • Dr. Ernest Pedapati, Cincinnati Children’s Hospital
    • Dr. Khaleel Razak, UC Riverside
    • Dr. Matthew Mosconi, University of Kansas
    • Dr. Brett Clementz, University of Georgia
    • Dr. Elizabeth Berry-Kravis, Rush University Medical Center
    • Dr. Carlos Portera-Cailliau, UCLA
    • Dr. Alexander Kolevzon, Mt. Sinai Medical Center
    • Dr. Matthew Byerly, Montana State University
    • Dr. Jun Wang, Zhejiang Normal University, China

    Publications

    2017

    Wang, J., Ethridge, L.E., Mosconi, M.W., White, S.P., Binder, D.K., Pedapati, E.V., Erickson, C. A., Byerly, M.J., Sweeney, J.A. (2017). A resting EEG study of neocortical hyperexcitability and altered functional connectivity in Fragile X Syndrome. Journal of Neurodevelopmental Disorders, 9:11.

    Hudgens-Haney, M.E., Ethridge, L.E., Knight, J.B., McDowell, J.E., Keedy, S.K., Pearlson, G.D., Tamminga, C.A., Keshavan, M.S., Sweeney, J.A., Clementz, B.A. (2017). Intrinsic neural activity differences among psychotic illnesses. Psychophysiology,54(8), 1223–1238.

    Shou, G., Mosconi, M.W., Wang, J., Ethridge, L.E., Sweeney, J.A., Ding, L. (2017). Electrophysiological signatures of atypical intrinsic brain connectivity networks in autism. Journal of Neural Engineering, 14(4):046010.

    Ethridge, L.E., White, S.P., Mosconi, M.W., Wang, J., Pedapati, E.V., Erickson, C., Byerly, M.J., Sweeney, J.A. (2017). Neural synchronization deficits linked to cortical hyper-excitability and auditory sensitivity in Fragile X Syndrome. Molecular Autism, 8:22.

    Hudgens-Haney, M.E., Ethridge, L.E., Knight, J.B., McDowell, J.E., Keedy, S.K., Pearlson, G.D., Tamminga, C.A., Keshavan, M.S., Sweeney, J.A., Clementz, B.A. (2017).Psychosis subgroups differ in intrinsic neural activity but not task-specific processing. Schizophrenia Research, in press.

    2016

    Ethridge, L.E., White, S.P., Mosconi, M.W., Wang, J. Byerly, M.J., Sweeney, J.A. (2016). Reduced habituation of auditory evoked potentials indicate cortical hyperexcitability in Fragile X Syndrome. Translational Psychiatry, 6: e787.

    Clementz, B.A., Sweeney, J.A, Hamm, J.P., Ivleva, E.I., Ethridge, L.E., Pearlson, G.D., Keshavan, M., Tamminga, C.A. (2016). Identification of distinct psychosis biotypes using brain-based biomarkers. American Journal of Psychiatry, 173(4): 373-384.

    2015

    Ethridge, L.E. Soilleux, M., Nakonezny, P.A., Reilly, J.L., Hill, S.K., Keefe, R.S.E., Gershon, E.S., Pearlson, G., Tamminga, C.A., Keshavan, M.S., Sweeney, J.A. (2015). Behavioral response inhibition in psychotic disorders: Diagnostic specificity, familiality, and relation to generalized cognitive deficit. Schizophrenia Research, 159(2-3): 491-498.

    Ethridge, L.E., Hamm, J.P., Pearlson, G.D., Tamminga, C.A., Sweeney, J.A., Keshavan, M.S., Clementz, B.A. (2015). Event-related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder. Biological Psychiatry, 77(2): 127-136.

    Narayanan, B., Ethridge, L.E., O’Neil, K., Dunn, S., Mathew, I., Tandon, N., Calhoun, V.D., Ruano, G., Kocherla, M., Windemuth, A., Clementz, B.A., Tamminga, C.A., Sweeney, J.A., Keshavan, M.S., Pearlson, G.D. Genetic sources of subcomponents of event-related potential in the dimension of psychosis analyzed from the BSNIP study. American Journal of Psychiatry, epub ahead of print DOI: 10.1176/appi.ajp.2014.13101411.

    Older

    Hamm, J.P., Ethridge, L.E., Boutros, N.N., Keshavan, M.S., Sweeney, J.A., Pearlson, G.D., Tamminga, C.A., Clementz, B.A. (2014) Diagnostic Specificity and Familiality of Early versus Late Evoked Potentials to Auditory Paired-Stimuli across the Schizophrenia-Bipolar Psychosis Spectrum. Psychophysiology, 51(4): 348-357.

    Ethridge, L.E., Malone, S.M., Iacono, W.G., Clementz, B.A. (2013) Genetic influences on composite neural activations supporting visual target identification. Biological Psychology, 92(2):329-341.

    Hamm, J.P., Ethridge, L.E., Shapiro, J.R., Pearlson, G., Tamminga, C.A., Sweeney, J.A., Keshavan, M.S., Thaker, G., Clementz, B.A. (2013) Family history of psychosis moderates auditory neural abnormalities in non-psychotic bipolar disorder. Bipolar Disorders,15: 774-786.

    Wang, J., Barstein, J., Ethridge, L.E., Mosconi, M., Takarae, Y., Sweeney, J.A. (2013) Resting state EEG abnormalities in autism spectrum disorders. Journal of Neurodevelopmental Disorders, 5(1):24. *(“Highly accessed” designation awarded through BioMed Central)

    Hamm, J.P., Ethridge, L.E., Shapiro, J.R., Stevens, M.C., Boutros, N.N., Summerfelt, A.T., Keshavan, M.S., Sweeney, J.A., Pearlson, G., Tamminga, C.A., Thaker, G., Clementz, B.A. (2012) Spatio-temporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and psychotic bipolar disorder. Psychophysiology,49(4):522-530.

    Ethridge, L.E., Hamm, J.P., Shapiro, J.R., Thaker, G., Summerfelt, A.T., Keedy, S.K., Stevens, M.C., Pearlson, G., Boutros, N.N., Tamminga, C.A., Sweeney, J.A., Keshavan, M.S., Clementz, B.A. (2012). Neural activations during auditory oddball processing discriminating schizophrenia and psychotic bipolar disorder. Biological Psychiatry,72(9):766-774.

    Ethridge, L.E., Moratti, S., Gao, Y., Keil, A., Clementz, B.A. (2011). Sustained versus transient brain responses in schizophrenia: The role of intrinsic neural activity. Schizophrenia Research, 133:106-111.

    Knight, J.B., Ethridge, L.E., Marsh, R.L., Clementz, B.A. (2010). Neural correlates of attentional and mnemonic processing in event-based prospective memory. Frontiers in Human Neuroscience, Feb.9; 4:5. doi:10.3389/neuro.09.005.2010

    Hamm, J.P., Dyckman,.K.A., Ethridge., L.E., McDowell., J.E., Clementz, B.A. (2010). Preparatory activations across a distributed cortical network determine production of express saccades in humans. Journal of Neuroscience, 30(21): 7350-7.

    Ethridge, L.E., Brahmbhatt, S., Gao, Y., McDowell, J.E., Clementz, B.A. (2009). Consider the context: blocked versus interleaved presentation of antisaccade trials. Psychophysiology, 46(5): 1100-7.