Answer and Discussion of Quiz Set: A-005

3.    Which of the followings is NOT a common histopathologic finding for Whipple’s disease?

A.  Foamy macrophages infiltration in the lamina propria

B.  Present with a variable amount of neutrophils

C.  Scattered fat droplets in the lamina propria

D.  Prominent plasma cells infiltration

E.  Vacuolization in the surface enterocytes

      Answer and Discussion: The answer is (D). Whipple’d disease is typically present with foamy macrophages infiltration in the lamina propria. Variable amounts of neutrophils are usually present, but mononuclear cell infiltrate is not a common feature for Whipple’s disease.