Answer and Discussion of Quiz Set: A-006

1.    To make a diagnosis of Barrett esophagus, you will need which of the following findings? 

A.  Characteristic endoscopic finding and biopsy showing dysplastic esophageal mucosa

B.  Biopsy showing dysplastic esophageal mucosa

C.  Characteristic endoscopic finding

D.  Biopsy showing esophageal mucosa with intestinal metaplasia and goblet cells

E.  Characteristic endoscopic finding and biopsy showing esophageal mucosa with intestinal metaplasia and goblet cells

Answer and Discussion: The answer is (E). Both endoscopic finding (Salmon-pink velvety tongues of glandular mucosa) and microscopic finding (intestinal metaplasia and goblet cells) are required to make a diagnosis. It should be noted that in Japan and United Kingdom, goblet cells are not required for the diagnosis of Barrett’s esophagus.