Answer and Discussion of Quiz Set: K-003

3.    Adrenal cortical tumors are positive for all of the following markers except which one?

A.  Melan A.

B.  Epithelial membrane antigen (EMA).

C.  Synaptophysin.

D.  Inhibin.

E.  Calretinin.

Answer and Discussion: The answer is (B). Adrenal cortical tumors are typically positive for inhibin, vimentin, calretinin, Melan A, and steroidogenic factor-1 (SF-1). These tumors are often positive for synaptophysinbut negative for chromogranin. The tumor cells are also negative for cytokeratin and EMA.