Answer and Discussion of Quiz Set: N-017

2.    Which of the following molecular genetic changes in an oligodendroglioima indicates more favorable prognosis?

A.  Deletion of chromosoome 22q

B.  Isochromosome 17

C.  Mutation of p53 gene

D.  Deletion of chromosome 1p and 19q

E.  Mutation of TSC1 and TSC2 gene

Answer and Discussion: The answer is (D). Deletion of chromosome 1p and 19q is associated with more favorable response to chemotherapy and therefore with better prognosis. Deletion of chromosome 22q is seen in atypical teratoid rhabdoid tumor, isochromosome is seen in medulloblastoma, mutation of p53 gene is seen in a variety of tumor arising from different part of the body, and mutation of TSC1 and TSC2 are associated with tuberous sclerosis.