Answer and Discussion of Quiz Set: N-019

5.    Which of the following has better prognosis than diffuse astrocytoma (WHO grade II)?

A.  Atypical teratoid/rhabdoid tumor (AT/RT)

B.  Medulloblastoma

C.  Glioblastoma

D.  Gemistocytic astrocytoma

E.  Dysembryoplastic neuroepithelial tumor (DNET)

Answer and Discussion: The answer is (E). DNET is a benign tumor (WHO grade I). It is a glial neuronal tumor with extensive mucoid changes. Although gemistocytic astrocytoma is WHO grade II, it has less favorable prognosis in comparison with classic diffuse astrocytoma. AT/RT, medulloblastoma, and glioblastomas are all high grade tumors.