Answer and Discussion of Quiz Set: N-027

3.    Which of the followings is not true about secretory meningioma?

A.  These tumors contain gland-like structures with eosinophilic, periodic acid Schiff (PAS) stain positive material.

B.  Keratin and carcinoembryonic antigen (CEA) are typically positive around these vacuoles.

C.  Histologically the gland-like structures may suggest metastatic carcinoma.

D.  They rarely exist in pure form and classic meningotheliomatous areas are typically present.

E.  Secretory meningiomas are seldom associated with impressive edema.

Answer and Discussion: The answer is (E). Secretory meningiomas have a reputation of generating impressive edema around the tumor that is typically disproportionally large in reference to the size of the tumor. [Link to a case of secretory meningioma with online slide]