Resident level quizzes are in crimson, student level quizzes are in blue.

Quiz Set: N-001

Kar-Ming Fung, M.D., Ph.D.

1.    Which of the following hormone is not produced in the anterior pituitary?  Answer

A.  Melatonin

B.  Prolactin

C.  Follicle stimulating hormone

D.  Growth hormone

E.  Luteinizing hormone

2.    Parinaud syndrome is characterized by paralysis of upward gaze, Pseudo-Argyll Robertson pupils, Convergence-Retraction nystagmus, Eyelid retraction (Collier sign), and Conjugate down gaze in the primary position ("sun-setting" sign). This syndrome is resulted from comprised function of which part of the brain?  Answer

A.  Medial and lateral genigulate nucleus

B.  Circuit of Papez

C.  Triangle of Guillain and Molaret

D.  Dorsal midbrain at the level of mesencephalic tectum (quadrigeminal plate)

E.  Hypothalamus-pituitary axis

3.    A 72 year-old retired engineer was brought to the hospital by his family because of unstable gait and urinary incontinence. On physical examination, the patient was well developed, well developed, and with not sign of distress. On neurologic examination, there were no focal signs. You also confirmed the family members' impression of forgetfulness and inability to do simple calculation. The patient, however, was mentally clear but apathic, well oriented, and free of hallucination. Fundic examination was within normal limits. Physical examination does not reveal any constitutional symptoms such as fever. What is the most likely diagnosis?  Answer

A.  Infarction in the territory supplied by the left middle cerebral artery

B.  Herpes simplex encephalitis

C.  Aqueductal stenosis

D.  Normal pressure hydrocephalus

E.  The patient's symptoms resulted from normal aging and has no ongoing pathologic process.

4.    Which of the following is not true about immunohistochemistry for OCT-4?  Answer

A.  OCT-4 is a transcription factor in embryonic stem cells and germ cells that maintains and regulates pluripotency of these cells.

B.  Its genuine positive immunoreactivity is cytoplasmic labeling.

C.  It is positive in seminoma and embryonal cell carcinoma but negative in yolk sac tumor and choriocarcinoma.

D.  Seminoma cells in tumors with heavy inflammatory cell infiltration can be detected by immunohistochemistry for OCT-4, placental alkaline phosphatase (PLAP) and CD117 (c-kit).

5.    Which of the following is not true?  Answer

A.  The highest incidence of germ cell tumor in the brain is pineal followed by the pituitary gland area.

B.  Interphotoreceptor retinoid-binding protein (IRBP) is positive in pineal parenchymal tumors and retinoblastomas but negative in medulloblastomas.

C.  Pineal parenchymal tumor of intermediate differentiation belongs to WHO grade II and grade III.

D.  Giant rosette is a feature of pineocytoma.

E.  In human, the pineal reaches its adult size at about 2 years old.

6.    Pineal germinoma is the only primary tumor of the central nervous that develop significant granulomatous changes?  Answer

A.  True

B.  False

Last updated: November, 20, 2011. Contributed by Kar-Ming Fung, M.D., Ph.D.

Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.