Answer and Discussion of Quiz Set: N-001
6. Pineal germinoma is the only primary tumor of the central nervous that develop significant granulomatous changes? Answer
A. True
B. False
Answer and Discussion: The answer is (B). Although pineal germinoma has the reputation of granulomatous changes to the extent that recognition of the neoplastic cells become a difficult task, granulomatous changes can also occur in other tumor particularly lymphoma where recognition of the neoplastic is also a challenging task.
Further Reading:
1. Kraichoke S, Cosgrove M, Chandrasoma PT. Granulomatous inflammation in pineal germinoma. A cause of diagnostic failure at stereotaxic brain biopsy. American Journal of Surgical Pathology. 1988 Sep;12(9):655-60.