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Quiz Set: N-017

Kar-Ming Fung, M.D., Ph.D.

1.    Which of the following is the most common site for oligodendrogliomas?  Answer

A.  Frontal and parietal lobe of the cerebral hemispheres

B.  Cerebellum

C.  Brainstem (midbrain, pons, medulla)

D.  Spinal cord

E.  Optic nerve

2.    Which of the following molecular genetic changes in an oligodendroglioima indicates more favorable prognosis?  Answer

A.  Deletion of chromosoome 22q

B.  Isochromosome 17

C.  Mutation of p53 gene

D.  Deletion of chromosome 1p and 19q

E.  Mutation of TSC1 and TSC2 gene

3.    Which of the following locations are most common for pilocytic astrocytoma?  Answer

A.  Frontal and parietal lobe of the cerebral hemispheres

B.  Cerebellum

C.  Brainstem (midbrain, pons, medulla)

D.  Spinal cord

E.  Optic nerve

4.    Which of the following is not true regarding oligodendroglioima?  Answer

A.  Oligodendroglioma (WHO grade II) typically occurs as a solitary hypointense or mixed hypointense and hyperintense mass on T1-weighted images, and a hyperintense mass on T2-weighted images. Edema in surrounding tissue is variable and these tumors, in general, do not enhance,

B.  Calcifications are typical findings in oligodendroglioma.

C.  Tumor cells are always negative for glial fibrillary acidic protein (GFAP).

D.  Tumor cells are often positive for Olig2.

E.  Mitoses are either scant or not found.

5.    Which of the following is true regarding primary (diffuse) leptomeningeal oligodendrogliomatosis?  Answer

A.  It is a common and benign condition that are seen mostly as an incidental finding in autopsy.

B.  It occurs in both children and adults.

C.  It does not associate with or connect to a space occupying oligodendroglioma.

D.  It is not a part of the spectrum of gliomatosis cerebri.

E.  It may simulate leptomeningeal dissemination of a clear cell carcinoma.

Last updated: October, 20, 2011. Contributed by Kar-Ming Fung, M.D., Ph.D.

Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.