1. To determine how normal cells become cancer cells.

2. To develop drugs to prevent normal cells from becoming cancer cells.

3. To develop drugs that kill cancer cells without harming normal cells.

3a. Retinoids

3b. Development of Heteroarotinoids (Hets)

3c. Development of Flex-Hets

3d. Lead Compound, SHetA2

4. To identify molecules that can be used as markers of cancer and drug response.