Resident level quizzes are in crimson, student level quizzes are in blue.

Quiz Set: N-027

Kar-Ming Fung, M.D., Ph.D.

1.    Which of the followings is not true about meningioma?  Answer

A.  High mitotic rate (4 per 10 high power fields) is one of the diagnostic criteria for atypical meningioma (WHO grade II).

B.  Brain invasion is one of the diagnostic criteria for atypical meningioma (WHO grade II).

C.  Invasion into adjacent bone  is one of the diagnostic criteria for atypical meningioma (WHO grade II).

D.  Papillary meningioma and rhabdoid meningioma are anaplastic meningiomas (WHO grade III).

E.  Meningiomas are positive for epithelial membrane antigen (EMA).

2.    Which of the followings is not true about meningioma?  Answer

A.  Meningiomas are negative for cytokeratin.

B.  S100 protein may have a patchy immunoreactivity in meningiomas.

C.  Psammomatous meningiomas are WHO grade I tumor if there is no histologic features indicative of aggressive behavior or malignancy behavior.

D.  Interdigitating cytoplasmic process is one of the ultrastructural features of meningiomas.

E.  Meningiomas are typically contrast enhancing.

3.    Which of the followings is not true about secretory meningioma?  Answer

A.  These tumors contain gland-like structures with eosinophilic, periodic acid Schiff (PAS) stain positive material.

B.  Keratin and carcinoembryonic antigen (CEA) are typically positive around these vacuoles.

C.  Histologically the gland-like structures may suggest metastatic carcinoma.

D.  They rarely exist in pure form and classic meningotheliomatous areas are typically present.

E.  Secretory meningiomas are seldom associated with impressive edema.

4.    Which of the followings is not true about chordoid meningioma and chordoma?  Answer

A.  Both of them typically have a bluish, myxomatous to chondroid background that is strongly positive for Alcian blue.

B.  Both of them can be positive for cytokeratin and epithelial membrane antigen (EMA).

C.  Both of them can be positive for S100 protein and immunoreactivity is typically patchy.

D.  Both of them are typically dural based.

E.  Chordoma but not chordoid meningioma is positive for Brachyury.

5.    Which of the following is true about meningioma in children?  Answer

A.  Meningiioma is a common tumor in children.

B.  These tumors occur more often in an infratentorial, intraventricular, or intraparenchymal location than those in adults.

C.  These tumors tend to be more aggressive and recur more frequently.

D.  They are more often associated with neurofibromatosis 2 (NF2).

E.  Meningioma and meningioangiomatosis are different entities and different in biological behavior.

Last updated: December, 20, 2011. Contributed by Kar-Ming Fung, M.D., Ph.D.

Dept. of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A.