As people age, the liver is among several organs that experience chronic, low-grade inflammation, a state that keeps the immune system activated even though there is no threat. Liver inflammation has been linked to several liver diseases, such as fatty liver disease and liver cancer, but the liver also communicates with the brain, triggering inflammation that can lead to cognitive decline. University of Oklahoma researcher Deepa Sathyaseelan, Ph.D., recently earned a $2 million grant from the National Institutes of Health to study the reasons behind this liver-brain crosstalk and test methods of protecting both organs.