https://ouhsc.edu/platelets/Thrombocytopenia Parent Page: Thrombocytopenia id: 31762 Active Page: DITP Database from Group Patient Reports - Literature Review through June, 2014id:33494

DITP Database from Group Patient Reports - Literature Review through June, 2014

Database for Drug-Induced Thrombocytopenia from Group Patient Reports: An Update

Total TCP = Total number of patients with thrombocytopenia.
EX TCP = The number of people in the experimental group that developed thrombocytopenia.
CT TCP = The number of people in the control group that developed thrombocytopenia.
For definition of Score and Exclusion criteria, click here.

Drug Name Citation Year Age Total TCP EX TCP CT TCP Score Exclusion

ABCIXIMAB

CIRCULATION 89:596-603

1994

Adult

     

5

1

ABCIXIMAB

NEJM 330:956-961

1994

Adult

86

62

24

4

NA

ABCIXIMAB

LANCET 349:1429-1435

1997

Adult

36

29

7

1

NA

ABCIXIMAB

NEJM 336:1689-1696

1997

Adult

16

12

4

4

NA

ABCIXIMAB

J AM COLL CARDIOL  31:55A

1998

Unknown

6

6

 

3

NA

ABCIXIMAB

CATHETER CARDIOVASC INTERV 47:294-296

1999

Adult

1

1

 

3

NA

ABCIXIMAB

CIRCULATION 104:870-875

2001

Adult

23

23

0

3

NA

ABCIXIMAB

LANCET 357:1905-1914

2001

Adult

298

243

55

1

NA

ABCIXIMAB

LANCET 357:1915-1924

2001

Adult

331

305

26

1

NA

ABCIXIMAB

NEJM 344:1888-1894

2001

Adult

102

16

86

1

NA

ABCIXIMAB

ANN HEMATOL 81:76-79

2002

Adult

8

   

3

NA

ABCIXIMAB

AM J CARDIOL 93:453-455

2004

Adult

11

0

11

2

NA

ABCIXIMAB

CARDIOL 102:184-187

2004

Adult

28

28

 

3

NA

ABCIXIMAB

CIRCULATION 109:2203-2206

2004

Adult

99

57

12

1

NA

ABCIXIMAB

CIRCULATION 109:2203-6

2004

Adult

 

58

12

1

NA

ABCIXIMAB

THROMB HAEMOST 92:820-8

2004

Adult

6

   

3

NA

ABCIXIMAB

J INTERV CARDIOL 18:33-37

2005

Adult

13

13

 

3

NA

ABCIXIMAB

AM J CARDIOL 97:426-9

2006

Adult

     

5

1

ACENOCOUMAROL

CLIN APPL THROMB HEMOST 8:213-215

2002

Both

     

5

1

ACETAMINOPHEN

BLOOD 82: 2714-2718

1993

Adult

10

   

4

NA

ADALIMUMAB

J DRUGS DERMATOL 10:280-4

2011

Adult

     

5

1

ALEMTUZUMAB

N ENGL J MED 359:1786-801

2008

Pediatric

 

6

1

5

5

ALEMTUZUMAB

BLOOD 118:6299-305

2011

Adult

     

5

5

ALTEPLASE

J AM COLL CARDIOL 11:1-11

1988

Unknown

     

5

1

ALTEPLASE

J AM COLL CARDIOL  23:891-898

1994

Adult

     

5

1

AMPHOTERICIN B

AM J DIS CHILD 133:731-4

1979

Both

     

5

1

ANTITHYMOCYTE GLOBULIN

DIABETES RES 2:271-6

1985

Pediatric

3

3

0

5

7

ARGATROBAN

ANN THORAC SURG 85:1651-5

2008

Adult

16

80

 

3

NA

ARGATROBAN

J THROMB THROMBOLYSIS 29:1-7

2010

Adult

     

5

1

ARGATROBAN

PEDIATR BLOOD CANCER 56:1103-9

2011

Pediatric

     

5

3

ASPIRIN

ANN RHEUM DIS 22:440-443

1963

Unknown

     

5

1

AT G-F; FRESENIUS (LYMPHOGLOBULIN)

EXP CLIN TRANSPLANT 2:178-82

2004

Adult

     

5

3

ATENOLOL

BLOOD 82:2714-2718

1993

Adult

4

   

4

NA

AZATHIOPRINE

GUT 34:1081-5

1993

Adult

15

   

3

NA

AZATHIOPRINE

ALIMENT PHARMACOL THER 25:941-7

2007

Pediatric

     

4

NA

BIVALIRUDIN

AM HEART J 161:298-306

2011

Adult

98

98

 

3

NA

BORTEZOMIB

BLOOD 106:3777-3784

2005

Adult

68

68

 

5

3

CARBAMAZEPINE

AM J PSYCHIATRY 142: 1196-1199

1985

Adult

1

1

0

5

6

CARBAMAZEPINE

AM J PSYCHIATRY 152:413-418

1995

Pediatric

1

   

5

1

CARBAMAZEPINE

NEUROL INDIA 51:427

2003

Pediatric

     

5

1

CEFAZOLIN

PHARMACOTHERAPY 19:108-113

1999

Adult

73

4

69

4

NA

CEFTRIAXONE

AM J DIS CHILD 137:1048-51

1983

Pediatric

     

5

1

CEPHALEXIN

SCAND J INFECT DIS 2:53-8

1970

Both

     

5

1

CHLORTHALIDONE

ACTA MED SCAND 183:245-50

1968

Both

14

   

5

1

CILASTATIN/IMIPENEM

REV INFECT DIS 7: 5471-5475

1985

Adult

2

   

5

1

CILASTATIN/IMIPENEM

PHARMACOTHERAPY 19:108-113

1999

Adult

7

4

3

2

NA

CLOPIDOGREL

CATHETER CARDIOVASC INTERV 50:426-30

2000

Adult

16

11

5

2

NA

CYCLOCYTIDINE

CANCER TREAT REP 60:215-6

1976

Pediatric

     

5

1,3

DACTINOMYCIN/ ACTINOMYCIN

J PEDIATRICS  107: 611-614

1985

Pediatric

     

5

3

DACTINOMYCIN/ ACTINOMYCIN

MED PEDIATR ONCOL 41:483-485

2003

Pediatric

29

   

1

NA

DEFERASIROX

ANN TROP PAEDIATR

2011

Both

6

   

4

NA

DEFERIPRONE

J PAEDIATR CHILD HEALTH 47:812-7

2011

Both

9

   

5

1

DIFLUNISAL

CURR MED RES OPIN 9:568-77

1985

Adult

     

5

1

DIGOXIN

BLOOD 82: 2714-2718

1993

Adult

9

   

4

NA

DIGOXIN

BLOOD 82:2714-2718

1993

Adult

9

   

2

NA

DIPHTHERIA/TETANUS/PERTUSSIS VACCINE

PEDIATR INFECT DIS J 22:119-122

2003

Pediatric

8

   

3

NA

DIPYRIDAMOLE

BLOOD 82: 2714-2718

1993

Adult

8

   

2

NA

DIPYRIDAMOLE

BLOOD 82:2714-2718

1993

Adult

8

   

2

NA

EFALIZUMAB (RAPTIVA)

J DRUGS DERMATOL 10:280-4

2011

Adult

     

5

1

EPOETIN ALFA

AM J GASTROENTEROL 101:2275-82

2006

Adult

     

5

2

EPTIFIBATIDE

CIRCULATION 91:2151-2157

1995

Adult

2

2

0

4

NA

EPTIFIBATIDE

CIRCULATION 95:846-854

1997

Adult

19

14

5

4

NA

EPTIFIBATIDE

LANCET 349:1422-1428

1997

Adult

114

79

35

4

NA

EPTIFIBATIDE

NEJM 339:436-443

1998

Adult

635

318

317

1

NA

EPTIFIBATIDE

CIRCULATION 99:2892-2900

1999

Adult

454

227

227

4

NA

EPTIFIBATIDE

LANCET 356:2037-2044

2000

Adult

2

2

0

4

NA

EPTIFIBATIDE

J AM COLL CARDIOL 39:377-386

2002

Adult

13

15

0

1

NA

FAMOTIDINE

J NEUROSURG ANESTHESIOL 16:291-293

2004

Adult

28

17

11

2

NA

FILGRASTIM (GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF))

BLOOD 87:4916-7

1996

Adult

     

5

5

FILGRASTIM (GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF))

BLOOD 96:2049-54

2000

Both

     

5

5

FUROSEMIDE

BLOOD 82: 2714-2718

1993

Adult

6

   

4

NA

FUROSEMIDE

BLOOD 82:2714-2718

1993

Adult

6

   

2

NA

FUSIDIC ACID

INT J ANTIMICROB AGENTS 2:S3-9

1999

Unknown

     

5

1

GANCICLOVIR

BLOOD 99:1159-1164

2002

Both

     

5

1

GEMCITABINE

CLIN ONCOL 18:639

2006

Adult

     

5

3

GlYCOPROTEIN IIb/IIIa INHIBITOR

J AM COLL CARDIOL 57:1200-1

2011

Adult

     

5

1

GOLD

ARTHRITIS RHEUM 22:495-501

1979

Both

7

   

5

1

GOLD

SEMIN ARTHRITIS RHEUM 14:238-46

1985

Both

11

   

5

1

HEPATITIS A VACCINE

LANCET 345:1638

1995

Adult

     

3

NA

HEPATITIS B VACCINE

LANCET 345:1638

1995

Adult

8

   

3

NA

HEPATITIS B VACCINE

SCAND J INFECT DIS 30:115-8

1998

Pediatric

7

   

1

NA

HEPATITIS B VACCINE

PEDIATR INFECT DIS J 22:119-122

2003

Pediatric

3

   

3

NA

HYDROCHLOROTHIAZIDE

J PEDIATR 77:1097-8

1970

Pediatric

0

   

5

1

HYDROXYCHLOROQUINE

ANN RHEUM DIS 22:440-443

1963

Unknown

     

5

1

IBUPROFEN

PEDIATRICS 115:1529-35

2005

Pediatric

     

4

NA

INAMRINONE

CLIN PHARMACOL THER 53:661-7

1993

Pediatric

8

   

2

NA

INFLUENZA VACCINE

PEDIATR INFECT DIS J 22:119-122

2003

Pediatric

2

   

3

NA

INTEGRILIN

CIRCULATION 91: 2151-2157

1995

Adult

3

3

0

4

NA

INTERFERON ALPHA

HAEMATOLOGICA 85:63-6

2000

Adult

     

5

1

INTERFERON ALPHA

J HEPATOL 32:1041-1042

2000

Unknown

     

5

2,7

INTERFERON ALPHA

J MED VIROL 64:460-5

2001

Adult

     

5

1

LENALIDOMIDE

BR J HAEMATOL 138"640-3

2007

Adult

     

5

3,7

LEVETIRACETAM

EPILEPSIA 51(12):2492-5

2010

Adult

29

   

5

1

LINEZOLID

MED LETT DRUGS THER 42:45-46

2000

NA

     

5

1,3

LINEZOLID

PHARMACOTHERAPY 21:1010-1013

2001

Unknown

     

5

1,3

LINEZOLID

ANTIMICROB AGENTS CHEMOTHER 46:2723-2726

2002

Adult

     

5

1,3

LINEZOLID

INFECT DIS CLIN PRAC 11:198-204

2002

Adult

     

5

1,3

LINEZOLID

CID 34:695-698

2002

Adult

6

   

5

3

LINEZOLID

CID 35:348-349

2002

Adult

9

   

5

3

LINEZOLID

CLIN INFECT DIS 34:695-698

2002

Adult

6

   

5

3

LINEZOLID

CID 36:159-168

2003

Both

     

5

1,3

LINEZOLID

CLIN THER 25:980-982

2003

Adult

     

5

1,3

LINEZOLID

CID 37:1609-1616

2003

Adult

16

8

8

5

3

LINEZOLID

PEDIATR INFECT DIS J 22:S186-92

2003

Pediatric

12

10

2

5

3

LINEZOLID

CID 38:1058-1064

2004

Adult

4

3

1

5

3

LINEZOLID

CLINCAL INFECTIOUS DIS 38:1058-1064

2004

Adult

18

7

11

5

3

LINEZOLID

J ANTIMICROB CHEMOTHER 6:440

2005

Adult

12

12

 

5

3

LINEZOLID

CID 42:66-72

2006

Adult

49

79

43

5

3

LINEZOLID

INT J ANTIMICROB AGENTS 28:345-51

2006

Adult

27

65

22

5

3

LINEZOLID

INT J ANTIMICROB AGENTS 33:92-3

2009

Adult

     

5

1,3

LINEZOLID

CLIN THER 31:2126-33

2009

Adult

7

   

5

3

LINEZOLID

INT J ANTIMICROB AGENTS 36:179-81

2010

Adult

     

5

3

MEASLES VACCINE

NEJM 275:352-356

1966

Both

22

22

0

5

1,5

MEASLES VACCINE

PEDIATR INFECT DIS J 15:88-90

1996

Both

56

   

5

5

MEASLES VACCINE

PEDIATR INFECT DIS J 22:S186-S192

2003

Pediatric

2

   

5

5

MEASLES, MUMPS, RUBELLA VACCINE

(MMR VACCINE)

PEDIATR INFECT DIS J 15:44-48

1996

Pediatric

54

   

5

5

MEASLES, MUMPS, RUBELLA VACCINE

(MMR VACCINE)

ARCH DIS CHILD 84:227-229

2001

Pediatric

28

   

5

5,7

MEASLES, MUMPS, RUBELLA VACCINE

(MMR VACCINE)

PEDIATR INFECT DIS J 22:119-122

2003

Pediatric

46

   

5

5

MEASLES, MUMPS, RUBELLA VACCINE

(MMR VACCINE)

VACCINE 29:1319-23

2011

Adult

     

5

1,5

MEROPENEM

CLIN INFECT DIS 24:S222-30

1997

Adult

 

11

11

5

1

METHOTREXATE

BRIT J CANCER 22: 244-249

1968

NA

     

5

3

METOPROLOL

BLOOD 82:2714-2718

1993

Adult

2

   

4

NA

NEDAPLATIN

EUR J GYNAECOL ONCOL 31:517-21

2010

Adult

     

5

3

NICOTINAMIDE

KIDNEY INT 68:2911-2912

2005

       

5

2

NICOTINAMIDE

NEFROLOGIA 31:58-65

2011

Adult

     

4

NA

NITROFURANTION

ARCH INTERN  MED 128:399-404

1971

Both

     

5

1

PANTOPRAZOLE

EXPERT OPIN PHARMACOTHER 8:2025-28

2007

Adult

     

4

NA

PEGINTERFERON ALFA 2B

CLEVE CLIN J MED 71:S17-S21

2004

       

5

1

PEGINTERFERON ALFA 2B/RIBAVIRIN

LANCET 358:958-965

2001

Adult

     

5

1

PEGINTERFERON ALFA 2B/RIBAVIRIN

NEJM 347:975-982

2002

Adult

     

5

1

PENICILLAMINE

AUST N Z J MED 9:495-503

1979

Adult

7

7

 

5

3

PENICILLAMINE

ARTHRITIS RHEUM 23:158-64

1980

Adult

     

5

3

PENICILLAMINE

J PEDIATR 112:799-804

1988

Pediatric

0

0

0

5

2,3

PENICILLAMINE

ANN PHARMACOTHER 34:15-8

2000

Pediatric

0

   

5

2,3

PHENYTOIN

PHARMACOTHERAPY 19:108-113

1999

Adult

14

5

9

2

NA

PIPERACILLIN

PHARMACOTHERAPY 19:108-113

1999

Adult

12

5

7

2

NA

PNEUMOCOCCAL VACCINE

JAMA 292:1702-10

2004

Pediatric

12

   

5

1

PORCINE FACTOR VIII

THROMB HAEMOST 65:245-7

1991

Both

     

5

4

PROPRANOLOL

BLOOD 82:2714-2718

1993

Adult

4

   

4

NA

QI-SUPPLEMENTING/YIN-NOURISHING THERAPY

J TRADIT CHIN MED 31:277-81

2011

Both

     

5

1

QUININE

BLOOD 82:2714-2718

1993

Adult

14

   

2

NA

QUININE

AM J HEMATOL 70:313-317

2002

Both

     

5

1

RIFAMPIN

BR MED J 3:343-7

1971

Both

3

   

5

1

RIFAMPIN

POSTGRAD MED J 47:742-747

1971

Both

3

   

5

1

RIFAMPIN

SCAND J RESPIR DIS SUPPL 84:119-24

1973

Both

2

   

5

1

RIFAMPIN

TUBERCLE 55:81-9

1974

Both

1

   

5

1,7

RIFAMPIN

AM REV RESPIR DIS 116:807-20

1977

Both

5

   

5

1

RIFAMPIN

CHEST 75:441-7

1979

Both

     

5

1

RIFAMPIN

CHEST 76:782-4

1979

Both

     

5

1

RITUXIMAB

J CLIN ONCOL 15:3266-3474

1997

Adult

3

   

3

NA

SIROLIMUS

TRANSPLANTATION 69:2085-90

2000

Both

93

   

5

2

SIROLIMUS

TRANSPLANT PROC 33:2271-2

2001

Both

     

5

1

STREPTOKINASE

J AM COLL CARDIOL 11:1-11

1988

Unknown

     

5

1

SULFAMETHOXAZOLE

BLOOD 84:176-83

1994

Both

     

5

1

SULFISOXAZOLE

ARCH INTERN MED 128:399-404

1971

Both

     

5

1

SULFISOXAZOLE

BLOOD 84:176-83

1994

Both

     

5

1

TEICOPLANIN

BR J HAEMATOL 129:279-281

2005

Unknown

31

31

 

3

NA

TEMOZOLOMIDE

CANCER CHEMOTHER PHARMACOL 52:459-64

2003

Both

     

5

3

TEMOZOLOMIDE

NEURO ONCOL 9:47-52

2007

Adult

     

5

3

TEMOZOLOMIDE

NEURO ONCOL 11:825-32

2009

Adult

29

   

5

1,3

TICLOPIDINE

CIRC CARDIOVASC INTERV 2:348-51

2009

Adult

3

   

5

1

TIROFIBAN

CIRCULATION 94 (Suppl):I553

1996

Unknown

29

16

13

4

NA

TIROFIBAN

CIRCULATION 96:1445-1453

1997

Adult

23

13

10

4

NA

TIROFIBAN

NEJM 228:1488-1497

1998

Adult

28

19

9

4

NA

TIROFIBAN

NEJM 338:1488-1497

1998

Adult

21

15

6

4

NA

TIROFIBAN

NEJM 338:1498-1505

1998

Adult

24

18

6

1

NA

TIROFIBAN

PLATELETS 16:462-8

2005

Adult

11

   

3

NA

TIROFIBAN

EXPERT OPIN DRUG SAF 9:801-19

2010

Adult

     

5

1

TNFalpha/INFgamma

ANN RHEUM DIS 67:1145-52

2008

Pediatric

     

5

1

TNFalpha/INFgamma

J AM ACAD DERMATOL 60:781-5

2009

Adult

4

4

0

2

NA

TRIMETHOPRIM/SULFAMETHOXAZOLE

CLIN PHARM THER 9:550-560

1968

Adult

     

5

2,7

TRIMETHOPRIM/SULFAMETHOXAZOLE

ARCH INTERN MED 128:399-404

1971

Both

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

J INFECT DIS 128:SUPPL:607-12

1973

Both

25

   

3

NA

TRIMETHOPRIM/SULFAMETHOXAZOLE

LANCET 2:614-6

1974

Pediatric

11

10

1

2

NA

TRIMETHOPRIM/SULFAMETHOXAZOLE

J INFECT DIS 132:630-6

1975

Both

1

1

0

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

MED J AUST 2:5-7

1976

Both

31

   

3

NA

TRIMETHOPRIM/SULFAMETHOXAZOLE

MED J AUST 2:5-7

1978

Both

31

   

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

AM J DIS CHILD 135:1097-5

1981

Pediatric

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

AM J DIS CHILD 135:1100-1103

1981

Pediatric

6

6

0

2

NA

TRIMETHOPRIM/SULFAMETHOXAZOLE

AM J DIS CHILD 136:1029

1982

Pediatric

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

J PEDIATRIC 100:1002-3

1982

Pediatric

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

INFECTION 15 (Suppl 5):S248-S252

1987

NA

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

ARCH INTERN MED 148:2293-5

1988

Adult

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

J INTERN MED 228:353-360

1990

Both

     

5

1

TRIMETHOPRIM/SULFAMETHOXAZOLE

BR J CLIN PHARMACOL 43:649-651

1997

Adult

3

   

5

1

UROKINASE

J AM COLL CARDIOL  23:891-898

1994

Adult

     

5

1

VALGANCICLOVIR

DRUGS 61:1145-1150

2001

Adult

22

   

3

NA

VALPROIC ACID

EPILEPSIA 19:113-114

1978

Pediatric

6

   

5

3

VALPROIC ACID

ANN NEUROL 5:389-390

1979

Adult

10

   

5

3

VALPROIC ACID

ARCH DIS CHILD 57:681-4

1982

Both

15

   

5

3

VALPROIC ACID

EPILEPSIA 34:1098-101

1993

Both

12

0

0

5

3

VALPROIC ACID

NEUROLOGY 44:1418-22

1994

Both

 

2

 

5

3

VALPROIC ACID

PEDIATR NEUROL 14:303-307

1996

Pediatric

41

36

5

5

3

VALPROIC ACID

PHARMACOTHERAPY 21:1325-1330

2001

Both

31

   

5

1,3

VALPROIC ACID

AM J PSYCHIATRY 158:128-130

2001

Adult

10

   

5

3

VALPROIC ACID

HONG KONG MED J 7:15-21

2001

Pediatric

17

17

2

5

3

VALPROIC ACID

J CLIN PSYCHOPHARMACOL 23:451-458

2003

Adult

     

5

2,3

VALPROIC ACID

EPILEPSIA 47:1136-43

2006

Pediatric

     

5

3

VALPROIC ACID

EPILEPSIA 48:205-6

2007

Pediatric

0

   

5

2,3

VALPROIC ACID

EPILEPSIA 49:438-45

2007

Adult

71

41

6

5

3

VALPROIC ACID

BLOOD COAGUL FIBRINOLYSIS 19:375-82

2008

Pediatric

2

2

0

5

2,3

VALPROIC ACID

EPILEPSIA 49:438-45

2008

Both

47

31

4

5

3

VALPROIC ACID

J CLIN PSYCHOPHARMACOL 30:282-5

2010

Adult

6

   

5

3

VANCOMYCIN

PHARMACOTHERAPY 19:108-113

1999

Adult

26

9

17

2

NA

VANCOMYCIN

N ENGL J MED 356:904-10

2007

Unknown

     

5

1

VANCOMYCIN

NEJM 356: 904-10

2007

Adult

29

   

3

NA

WARFARIN

CLIN APPL THROMB HEMOST 8:213-215

2002

Both

28

   

5

1

Score and Exclusion Criteria Definitions:

ARTICLE SCORE:

  1. Thrombocytopenia definitely caused by drug. Inclusion criteria 1 and 4 met.
  2. Thrombocytopenia probably caused by drug. Inclusion criteria 2 and 4 met.
  3. Thrombocytopenia possibly caused by drug. Inclusion criteria 3 met.
  4. Thrombocytopenia unlikely caused by drug. Inclusion criteria 1 or 2 met, but criterion 4 not met.
  5. Excluded. (See reason for exclusion below.)

INCLUSION CRITERIA:

  1. The study was a prospective, randomized controlled trial.
  2. The study was a prospective cohort with a control group, not randomized.
  3. The study was a retrospective case control study or cohort study with a control group, or a prospective cohort study without a control group or a retrospective case series.
  4. There was significantly greater frequency of thrombocytopenia in patients treated compared to patients not treated with the suspected drug.

REASON FOR EXCLUSION:

  1. Insufficient clinical data with which to evaluate the relationship between drug administration and thrombocytopenia
  2. Platelet count of 100,000 cells/mL or more
  3. Agents that cause thrombocytopenia due to marrow suppression (i.e. chemotherapy, valproate, linezolid, penicillamine)
  4. Agents that cause thrombocytopenia due to accelerated clearance of platelets (i.e. porcine factor VIII or Desmopressin in patients with 2B VWD)
  5. Agents that cause sustained TCP without marrow suppression (possible ITP; i.e. MMR, G-CSF, Alemtuzumab)
  6. Patient exposed to nontherapeutic agent or experimental agent or used an agent in a nontherapeutic manner
  7. Drug-induced disease includes things other than thrombocytopenia
  8. Neonatal thrombocytopenia that was attributed to a drug taken by the mother

IMPORTANT!

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